| Contents per vial | 50 mg |
|---|---|
| Form | Lyophilized powder |
| Packaging | Sealed glass vial |
| Purity | 99,82 % (HPLC) |
| Storage | 2–8 °C, keep dry and protect from light |
| Molecular formula | C32H49N9O5 |
| Molecular weight | 639,79 g/mol |
| Sequence or structure | H-D-Arg–Dmt–Lys–Phe–NH2. |
| CAS | 736992-21-5 |
| Intended use | For laboratory research only |
About this product
SS-31, also known as elamipretide, is a mitochondria-targeted tetrapeptide. It is being investigated for its ability to interact with cardiolipin in the inner mitochondrial membrane and promote more efficient mitochondrial function. Clinical and preclinical research includes energy metabolism, muscle, heart, kidney, and diseases associated with mitochondrial dysfunction.
What is SS-31?
SS-31 / Elamipretide is classified as a “synthetic peptide or peptide analog” and is evaluated in scientific research in relation to areas such as mitochondrial function, ATP production, oxidative stress, muscle and heart bioenergetics. Attention is paid to its interaction with relevant receptors, enzymes or cellular pathways and subsequent changes in measurable laboratory parameters.
Mechanism of action under investigation
SS-31 concentrates in the inner mitochondrial membrane and interacts with cardiolipin. This can affect the organization of the respiratory chain, ATP production and oxidative stress.
MAIN AREAS OF RESEARCH
• Mitochondrial function: Elamipretide is a mitochondria-targeted peptide studied for the stabilization of processes that ensure efficient energy production in mitochondria.
• ATP formation: Research monitors the sensitivity of mitochondria to ADP and the formation of ATP, the main energy molecule of the cell.
• Oxidative stress: SS-31 is being investigated for its ability to limit the excessive generation of reactive oxygen species and damage to mitochondrial structures.
• Muscle and cardiac bioenergetics: Both experimental and clinical programs evaluate tissues with high energy consumption, especially skeletal muscle and the heart.
• Mitochondrial diseases: Elamipretide has also been studied in diseases associated with mitochondrial energy disorders, where muscle function and other clinical parameters are evaluated.
Research findings to date
Work to date on the substance SS-31 / Elamipretide are devoted to areas that include mitochondrial function, ATP production, oxidative stress, muscle and heart bioenergetics, mitochondrial diseases. Clinical and preclinical research includes energy metabolism, muscle, heart, kidney, and diseases associated with mitochondrial dysfunction. Clinical trial results vary between indications.
