| Contents per vial | 10 mg |
|---|---|
| Form | Lyophilized powder |
| Packaging | Sealed glass vial |
| Purity | 99,90 % |
| Storage | 2–8 °C, keep dry and protect from light |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174,59 g/mol |
| Sequence or structure | MRWQEMGYIFYPRKLR |
| CAS | 1627580-64-6 |
| Intended use | For laboratory research only |
About this product
MOTS-c is a mitochondrial-derived peptide investigated as a signaling molecule linking mitochondria to whole-cell metabolism. Research focuses on insulin sensitivity, glucose utilization, energy metabolism, physical performance and biological aging.
What is MOTS-c?
MOTS-c is characterized in this portfolio as a synthetic peptide or peptide analog intended for controlled laboratory investigation. Scientific interest is focused on insulin sensitivity, glucose utilization, physical performance, mitochondrial communication and related biochemical or receptor processes.
Mechanism of action under investigation
MOTS-c affects cellular energy pathways including AMPK and purine metabolism. During metabolic stress, it can change gene expression and use of energy substrates.
MAIN AREAS OF RESEARCH
• Energy metabolism: MOTS-c is a mitochondrially encoded peptide studied for its role in regulating how cells process glucose and respond to a lack of energy.
• Insulin sensitivity: Research is looking at the relationship of MOTS-c to insulin sensitivity and metabolic flexibility, i.e. the body’s ability to switch between different energy sources.
• Physical performance and muscles: MOTS-c is studied in relation to energy metabolism in skeletal muscles and adaptation to physical exertion.
• Mitochondrial communication: The peptide is of interest as a signal generated by mitochondria that can influence gene activity in the cell nucleus and the response to metabolic stress.
• Aging and physical capacity: Preclinical work is investigating whether changes in MOTS-c signaling are associated with declines in metabolic and physical capacity during aging.
Research findings to date
Work to date on MOTS-c has focused on areas including insulin sensitivity, glucose utilization, physical performance, mitochondrial communication, and aging. Research focuses on insulin sensitivity, glucose utilization, energy metabolism, physical performance and biological aging. There is observational and early experimental data in humans, but not enough evidence to make therapeutic claims. Available data on MOTS-c in humans are limited and much of the knowledge comes from cell and animal models.
