| Contents per vial | 5 mg |
|---|---|
| Form | Lyophilized powder |
| Packaging | Sealed glass vial |
| Purity | 98,98 % |
| Storage | 2–8 °C, keep dry and protect from light |
| Molecular formula | C18H14N2O2 |
| Molecular weight | 290,32 g/mol |
| Sequence or structure | 4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide) |
| CAS | 303760-60-3 |
| Intended use | For laboratory research only |
About this product
SLU-PP-332 is an experimental small molecule agonist of estrogen-related receptors (ERR), especially ERRα. It is being investigated as a tool to activate gene programs associated with oxidative metabolism and endurance adaptation. In research, it influenced energy expenditure and metabolic parameters.
What is SLU-PP-332?
From a scientific perspective, SLU-PP-332 represents a substance classified as a small synthetic molecule. Its experimental profile is mainly assessed through oxidative metabolism, energy expenditure, endurance adaptation, obesity and metabolism, while individual research questions can use different cell, tissue or organismal models. Binding to target structures, subsequent signaling and changes in selected biological indicators are monitored.
Mechanism of action under investigation
SLU-PP-332 activates ERR receptors, transcriptional regulators of energy metabolism. It can thereby alter the expression of mitochondrial and oxidative genes.
MAIN AREAS OF RESEARCH
• Oxidative metabolism: SLU-PP-332 is an experimental small molecule, not a peptide, that activates estrogen-related receptors ERR and promotes gene programs of oxidative metabolism.
• Energy expenditure: Preclinical research monitors changes in energy consumption and utilization of energy substrates during activation of ERR signaling.
• Endurance adaptation: Changes in muscle metabolism and endurance capacity associated with programs similar to part of the adaptive response to exercise are investigated in animal models.
• Obesity and metabolism: Research evaluates body weight, fat mass and metabolic parameters in models of obesity.
Research findings to date
Work to date on SLU-PP-332 has focused on areas including oxidative metabolism, energy expenditure, endurance adaptation, obesity and metabolism. Results should be assessed according to the level of evidence: cell and animal models.
