| Contents per vial | 5 mg |
|---|---|
| Form | Lyophilized powder |
| Packaging | Sealed glass vial |
| Purity | 99,73 % (HPLC) |
| Storage | 2–8 °C, keep dry and protect from light |
| Molecular formula | C188H293N53O44S |
| Molecular weight | 4031,73 g/mol |
| Sequence or structure | H-Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH |
| CAS | 1159861-00-3 |
| Intended use | For laboratory research only |
About this product
PNC-27 is an experimental peptide derived from p53 and linked to a membrane-active sequence, studied for antitumor effects. Laboratory work is investigating its ability to selectively damage certain tumor cells by interacting with HDM2 on the cell surface. It is mainly cellular and preclinical research.
What is PNC-27?
PNC-27 is classified as a “synthetic peptide or peptide analog” and is evaluated in scientific research in relation to areas such as tumor cells, HDM2 on the membrane, membrane pore formation. Attention is paid to its interaction with relevant receptors, enzymes or cellular pathways and subsequent changes in measurable laboratory parameters.
Mechanism of action under investigation
PNC-27 combines a p53-derived sequence with a membrane-penetrating part. The proposed mechanism involves binding to membrane HDM2 and pore formation.
MAIN AREAS OF RESEARCH
• Tumor cells: PNC-27 is an experimental peptide studied in laboratory models for selective damage to certain tumor cells.
• HDM2 on the cell membrane: The proposed mechanism is related to binding to HDM2, which is also found on the outer surface of the membrane in some tumor cells.
• Formation of membrane pores: In cell models, the formation of pores in the membrane and the subsequent loss of integrity of the tumor cell are investigated; clinical efficacy in humans has not been established.
Research findings to date
Work to date with the substance PNC-27 is devoted to areas that include tumor cells, HDM2 on the membrane, the formation of membrane pores. Results should be assessed according to the level of evidence: cell and animal models. It is mainly cellular and preclinical research.
