| Contents per vial | 10 mg |
|---|---|
| Form | Lyophilized powder |
| Packaging | Sealed glass vial |
| Purity | 99 % (HPLC) |
| Storage | 2–8 °C, keep dry and protect from light |
| Molecular formula | C45H55N9O6 |
| Molecular weight | 817,98 g/mol |
| Sequence or structure | D-Ala–D-2-Nal–Ala–Trp–D-Phe–Lys–NH2 |
| CAS | 158861-67-7 |
| Intended use | For laboratory research only |
About this product
GHRP-2 is a synthetic growth hormone secretagogue that activates the ghrelin receptor. In experimental and human studies, it can increase the secretion of growth hormone and affect the GH/IGF-1 axis. Research is also focused on appetite and neuroendocrine response, as the ghrelin receptor has multiple functions. GHRP-2 can also affect other hormones, which is important when evaluating selectivity. This is a research substance, not an approved muscle growth agent.
What is GHRP-2?
From a scientific perspective, GHRP-2 represents a substance classified as a synthetic peptide or peptide analog. Its experimental profile is mainly assessed through growth hormone secretion, GH/IGF-1 signaling, appetite, neuroendocrine response, while individual research questions can use different cell, tissue or organismal models. Binding to target structures, subsequent signaling and changes in selected biological indicators are monitored.
Mechanism of action under investigation
GHRP-2 activates the GHS-R1a receptor and stimulates the pituitary gland to release GH. The effect may be enhanced in the presence of GHRH signaling.
MAIN AREAS OF RESEARCH
• Secretion of growth hormone: GHRP-2 activates the ghrelin receptor GHSR-1a and is studied for a significant stimulation of the release of growth hormone from the pituitary gland.
• GH/IGF-1 signaling: Research follows subsequent changes in GH and IGF-1 and their time course after ghrelin receptor activation.
• Appetite: The ghrelin receptor is also involved in the regulation of hunger, so the relationship between hormonal stimulation and food intake is investigated with GHRP-2.
• Neuroendocrine response: GHRP-2 is used to investigate the connection between the hypothalamus, pituitary gland and ghrelin signaling, including the responses of other hormones.
Research findings to date
Results should be judged according to the level of evidence: cellular and animal. Research is also focused on appetite and neuroendocrine response, as the ghrelin receptor has multiple functions. This is a research substance, not an approved muscle growth agent. In research on GHRP-2, hormonal changes, increased appetite, possible changes in cortisol or prolactin and other effects associated with the ghrelin receptor are monitored.
