| Contents per vial | 5 mg |
|---|---|
| Form | Lyophilized powder |
| Packaging | Sealed glass vial |
| Purity | 98,39 % (HPLC) |
| Storage | 2–8 °C, keep dry and protect from light |
| Molecular formula | C60H98N16O20S |
| Molecular weight | 1395,58 g/mol |
| Sequence or structure | Arg-Pro-Arg-Pro-Asp-Asp-Leu-Glu-Ile |
| CAS | 916977-43-0 |
| Intended use | For laboratory research only |
About this product
Peptide 5 is a mimetic peptide associated with connexin 43, a protein forming gap junctions and hemichannels between cells. It is investigated in tissue damage, inflammation and pathological opening of connexin hemichannels. Research includes neural, cardiac and other tissue models. Most of the data is preclinical. Its importance lies mainly in the study of intercellular communication.
What is Peptide 5 / Connexin 43?
Peptide 5 / Connexin 43 is characterized in this portfolio as a synthetic peptide or peptide analog intended for controlled laboratory investigation. Scientific interest is focused on gap junctions and hemichannels, tissue damage, inflammation and related biochemical or receptor processes. Changes in predetermined markers, functional responses and signaling pathways are compared in experimental protocols.
Mechanism of action under investigation
Peptide 5 modulates channels formed by connexin 43. The goal is to limit the pathological activity of hemichannels while maintaining physiological intercellular communication.
MAIN AREAS OF RESEARCH
• Connexin 43 and hemichannels: Peptide 5 is a Connexin 43 mimetic peptide studied for regulating hemichannels, which may open excessively when tissue is damaged.
• Cellular communication: Research is looking at how changing the activity of Connexin 43 affects communication between neighboring cells and the propagation of damage signals.
• Tissue damage and inflammation: Preclinical models are investigating whether limiting pathologically open hemichannels can reduce secondary damage and the inflammatory response.
Research findings to date
Research includes neural, cardiac and other tissue models. Most of the data is preclinical.
