{"id":564,"date":"2026-10-27T12:16:34","date_gmt":"2026-10-27T12:16:34","guid":{"rendered":"https:\/\/virexionlabs.net\/product\/dermorphin-5mg\/"},"modified":"2026-10-27T12:16:34","modified_gmt":"2026-10-27T12:16:34","slug":"dermorphin-5mg","status":"publish","type":"product","link":"https:\/\/virexionlabs.net\/sk\/produkt\/dermorphin-5mg\/","title":{"rendered":"Dermorphin 5 mg"},"content":{"rendered":"<p>Dermorphin je prirodzene sa vyskytuj\u00faci opioidn\u00fd heptapeptid s vysokou afinitou k \u03bc-opioidn\u00e9mu receptoru. Sk\u00fama sa najm\u00e4 ako model ve\u013emi potentnej opioidnej signaliz\u00e1cie a analg\u00e9zie. Jeho farmakol\u00f3gia je v\u00fdrazne odli\u0161n\u00e1 od be\u017en\u00fdch v\u00fdskumn\u00fdch peptidov a zah\u0155\u0148a rizik\u00e1 typick\u00e9 pre opioidn\u00e9 agonisty. V\u00fdskum sa venuje receptorovej selektivite, bolesti a centr\u00e1lnej nervovej signaliz\u00e1cii.<\/p>\n<h2>\u010co je Dermorphin?<\/h2>\n<p>Z odborn\u00e9ho h\u013eadiska predstavuje Dermorphin l\u00e1tku zaraden\u00fa ako syntetick\u00fd peptid alebo peptidov\u00fd anal\u00f3g. Jej experiment\u00e1lny profil sa posudzuje najm\u00e4 cez \u03bc-opioidn\u00fd receptor, analgetick\u00e1 signaliz\u00e1cia, opioidn\u00e1 farmakol\u00f3gia, pri\u010dom jednotliv\u00e9 v\u00fdskumn\u00e9 ot\u00e1zky m\u00f4\u017eu vyu\u017e\u00edva\u0165 rozdielne bunkov\u00e9, tkanivov\u00e9 alebo organizmov\u00e9 modely. Sleduje sa v\u00e4zba na cie\u013eov\u00e9 \u0161trukt\u00fary, nadv\u00e4zuj\u00faca signaliz\u00e1cia a zmena vybran\u00fdch biologick\u00fdch ukazovate\u013eov.<\/p>\n<h2>Mechanizmus sk\u00faman\u00e9ho p\u00f4sobenia<\/h2>\n<p>Dermorphin aktivuje \u03bc-opioidn\u00e9 receptory a n\u00e1sledn\u00fa Gi\/o-prote\u00ednov\u00fa signaliz\u00e1ciu, ktor\u00e1 tlm\u00ed prenos bolestiv\u00fdch sign\u00e1lov a neur\u00f3nov\u00fa excitabilitu.<\/p>\n<h2>Hlavn\u00e9 oblasti v\u00fdskumu<\/h2>\n<p><strong>\u2022&nbsp; \u03bc-opioidn\u00fd receptor: <\/strong>Dermorphin je prirodzen\u00fd peptid s vysokou afinitou k \u03bc-opioidn\u00e9mu receptoru a pou\u017e\u00edva sa na sk\u00famanie jeho aktiv\u00e1cie a receptorovej selektivity.<\/p>\n<p><strong>\u2022&nbsp; Analgetick\u00e1 signaliz\u00e1cia: <\/strong>V\u00fdskum sa venuje nervov\u00fdm dr\u00e1ham, ktor\u00fdmi aktiv\u00e1cia \u03bc-opioidn\u00e9ho receptora men\u00ed prenos a vn\u00edmanie bolestiv\u00fdch podnetov.<\/p>\n<p><strong>\u2022&nbsp; Opioidn\u00e1 farmakol\u00f3gia: <\/strong>Dermorphin sl\u00fa\u017ei ako modelov\u00e1 molekula pri sk\u00faman\u00ed vz\u0165ahu medzi \u0161trukt\u00farou peptidu, v\u00e4zbou na opioidn\u00e9 receptory a biologickou odpove\u010fou.<\/p>\n<h2>Doteraj\u0161ie zistenia v\u00fdskumu<\/h2>\n<p>Jeho farmakol\u00f3gia je v\u00fdrazne odli\u0161n\u00e1 od be\u017en\u00fdch v\u00fdskumn\u00fdch peptidov a zah\u0155\u0148a rizik\u00e1 typick\u00e9 pre opioidn\u00e9 agonisty. V\u00fdskum sa venuje receptorovej selektivite, bolesti a centr\u00e1lnej nervovej signaliz\u00e1cii. Pre t\u00fato v\u00fdskumn\u00fa l\u00e1tku nie je k dispoz\u00edcii dostato\u010dne \u0161tandardizovan\u00fd klinick\u00fd bezpe\u010dnostn\u00fd profil.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Produkt Dermorphin sa dod\u00e1va ako 5 mg lyofilizovan\u00fd pr\u00e1\u0161ok v uzavretej sklenenej vialke. Ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rny v\u00fdskum. Nie je ur\u010den\u00fd na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie.<\/p>\n","protected":false},"featured_media":560,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[39,40,41],"class_list":["post-564","product","type-product","status-publish","has-post-thumbnail","product_cat-kognicia-a-mentalny-vykon","product_tag-lyophilised","product_tag-research-use-only","product_tag-third-party-tested","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.6 (Yoast SEO v25.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dermorphin 5 mg - VirexionLabs.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/virexionlabs.net\/sk\/produkt\/dermorphin-5mg\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dermorphin 5 mg\" \/>\n<meta property=\"og:description\" content=\"Produkt Dermorphin sa dod\u00e1va ako 5 mg lyofilizovan\u00fd pr\u00e1\u0161ok v uzavretej sklenenej vialke. 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