{"id":554,"date":"2026-10-27T12:16:29","date_gmt":"2026-10-27T12:16:29","guid":{"rendered":"https:\/\/virexionlabs.net\/product\/pnc-27-5mg\/"},"modified":"2026-10-27T12:16:29","modified_gmt":"2026-10-27T12:16:29","slug":"pnc-27-5mg","status":"publish","type":"product","link":"https:\/\/virexionlabs.net\/sk\/produkt\/pnc-27-5mg\/","title":{"rendered":"PNC-27 5mg"},"content":{"rendered":"<p>PNC-27 je experiment\u00e1lny protin\u00e1dorovo sk\u00faman\u00fd peptid odvoden\u00fd od p53, spojen\u00fd s membr\u00e1novo akt\u00edvnou sekvenciou. Laborat\u00f3rne pr\u00e1ce sk\u00famaj\u00fa jeho schopnos\u0165 selekt\u00edvne po\u0161kodzova\u0165 ur\u010dit\u00e9 n\u00e1dorov\u00e9 bunky prostredn\u00edctvom interakcie s HDM2 na bunkovom povrchu. Ide preva\u017ene o bunkov\u00fd a preklinick\u00fd v\u00fdskum. Neexistuje d\u00f4kaz, \u017ee by PNC-27 bol schv\u00e1lenou alebo overenou lie\u010dbou rakoviny u \u013eud\u00ed.<\/p>\n<h2>\u010co je PNC-27?<\/h2>\n<p>PNC-27 sa zara\u010fuje medzi l\u00e1tky typu \u201esyntetick\u00fd peptid alebo peptidov\u00fd anal\u00f3g\u201c a v odbornom v\u00fdskume sa hodnot\u00ed v s\u00favislosti s oblas\u0165ami ako n\u00e1dorov\u00e9 bunky, HDM2 na membr\u00e1ne, tvorba membr\u00e1nov\u00fdch p\u00f3rov. Pozornos\u0165 sa venuje jeho interakcii s pr\u00edslu\u0161n\u00fdmi receptormi, enz\u00fdmami alebo bunkov\u00fdmi dr\u00e1hami a n\u00e1sledn\u00fdm zmen\u00e1m merate\u013en\u00fdch laborat\u00f3rnych parametrov.<\/p>\n<h2>Mechanizmus sk\u00faman\u00e9ho p\u00f4sobenia<\/h2>\n<p>PNC-27 kombinuje p53-derived sekvenciu s membr\u00e1novo penetruj\u00facou \u010das\u0165ou. Navrhovan\u00fd mechanizmus zah\u0155\u0148a v\u00e4zbu na membr\u00e1nov\u00fd HDM2 a tvorbu p\u00f3rov.<\/p>\n<h2>Hlavn\u00e9 oblasti v\u00fdskumu<\/h2>\n<p><strong>\u2022&nbsp; N\u00e1dorov\u00e9 bunky: <\/strong>PNC-27 je experiment\u00e1lny peptid sk\u00faman\u00fd v laborat\u00f3rnych modeloch pre selekt\u00edvne po\u0161kodenie ur\u010dit\u00fdch n\u00e1dorov\u00fdch buniek.<\/p>\n<p><strong>\u2022&nbsp; HDM2 na bunkovej membr\u00e1ne: <\/strong>Navrhovan\u00fd mechanizmus s\u00favis\u00ed s v\u00e4zbou na HDM2, ktor\u00fd sa pri niektor\u00fdch n\u00e1dorov\u00fdch bunk\u00e1ch nach\u00e1dza aj na vonkaj\u0161om povrchu membr\u00e1ny.<\/p>\n<p><strong>\u2022&nbsp; Tvorba membr\u00e1nov\u00fdch p\u00f3rov: <\/strong>V bunkov\u00fdch modeloch sa sk\u00fama vytv\u00e1ranie p\u00f3rov v membr\u00e1ne a n\u00e1sledn\u00e1 strata integrity n\u00e1dorovej bunky; klinick\u00e1 \u00fa\u010dinnos\u0165 u \u013eud\u00ed nebola preuk\u00e1zan\u00e1.<\/p>\n<h2>Doteraj\u0161ie zistenia v\u00fdskumu<\/h2>\n<p>Doteraj\u0161ie pr\u00e1ce pri l\u00e1tke PNC-27 sa venuj\u00fa oblastiam, medzi ktor\u00e9 patria n\u00e1dorov\u00e9 bunky, HDM2 na membr\u00e1ne, tvorba membr\u00e1nov\u00fdch p\u00f3rov. V\u00fdsledky treba posudzova\u0165 pod\u013ea \u00farovne d\u00f4kazov: bunkov\u00e9 a zvieracie modely. Ide preva\u017ene o bunkov\u00fd a preklinick\u00fd v\u00fdskum.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Produkt PNC-27 sa dod\u00e1va ako 5 mg lyofilizovan\u00fd pr\u00e1\u0161ok v uzavretej sklenenej vialke. Ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rny v\u00fdskum. Nie je ur\u010den\u00fd na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie.<\/p>\n","protected":false},"featured_media":550,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[19],"product_tag":[39,40,41],"class_list":["post-554","product","type-product","status-publish","has-post-thumbnail","product_cat-imunitne-zdravie","product_tag-lyophilised","product_tag-research-use-only","product_tag-third-party-tested","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.6 (Yoast SEO v25.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PNC-27 5mg - VirexionLabs.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/virexionlabs.net\/sk\/produkt\/pnc-27-5mg\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PNC-27 5mg\" \/>\n<meta property=\"og:description\" content=\"Produkt PNC-27 sa dod\u00e1va ako 5 mg lyofilizovan\u00fd pr\u00e1\u0161ok v uzavretej sklenenej vialke. 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