{"id":553,"date":"2026-10-27T12:16:29","date_gmt":"2026-10-27T12:16:29","guid":{"rendered":"https:\/\/virexionlabs.net\/product\/pnc-27-5mg\/"},"modified":"2026-10-27T12:16:29","modified_gmt":"2026-10-27T12:16:29","slug":"pnc-27-5mg","status":"publish","type":"product","link":"https:\/\/virexionlabs.net\/cs\/produkt\/pnc-27-5mg\/","title":{"rendered":"PNC-27 5 mg"},"content":{"rendered":"<p>PNC-27 je experiment\u00e1ln\u00ed protin\u00e1dorov\u011b zkouman\u00fd peptid odvozen\u00fd od p53, spojen\u00fd s membr\u00e1nov\u011b aktivn\u00ed sekvenc\u00ed. Laboratorn\u00ed pr\u00e1ce zkoumaj\u00ed jeho schopnost selektivn\u011b po\u0161kozovat ur\u010dit\u00e9 n\u00e1dorov\u00e9 bu\u0148ky prost\u0159ednictv\u00edm interakce s HDM2 na bun\u011b\u010dn\u00e9m povrchu. Jedn\u00e1 se p\u0159ev\u00e1\u017en\u011b o bun\u011b\u010dn\u00fd a preklinick\u00fd v\u00fdzkum. Neexistuje d\u016fkaz, \u017ee by PNC-27 byl schv\u00e1lenou nebo ov\u011b\u0159enou l\u00e9\u010dbou rakoviny u lid\u00ed.<\/p>\n<h2>Co je PNC-27?<\/h2>\n<p>PNC-27 se \u0159ad\u00ed mezi l\u00e1tky typu \u201esyntetick\u00fd peptid nebo peptidov\u00fd analog\u201c a v odborn\u00e9m v\u00fdzkumu se hodnot\u00ed v souvislosti s oblastmi jako n\u00e1dorov\u00e9 bu\u0148ky, HDM2 na membr\u00e1n\u011b, tvorba membr\u00e1nov\u00fdch p\u00f3r\u016f. Pozornost se v\u011bnuje jeho interakci s p\u0159\u00edslu\u0161n\u00fdmi receptory, enzymy nebo bun\u011b\u010dn\u00fdmi dr\u00e1hami a n\u00e1sledn\u00fdm zm\u011bn\u00e1m m\u011b\u0159iteln\u00fdch laboratorn\u00edch parametr\u016f.<\/p>\n<h2>Mechanismus zkouman\u00e9ho p\u016fsoben\u00ed<\/h2>\n<p>PNC-27 kombinuje p53-derived sekvenci s membr\u00e1nov\u011b penetruj\u00edc\u00ed \u010d\u00e1st\u00ed. Navrhovan\u00fd mechanismus zahrnuje vazbu na membr\u00e1nov\u00fd HDM2 a tvorbu p\u00f3r\u016f.<\/p>\n<h2>Hlavn\u00ed oblasti v\u00fdzkumu<\/h2>\n<p><strong>\u2022&nbsp; N\u00e1dorov\u00e9 bu\u0148ky: <\/strong>PNC-27 je experiment\u00e1ln\u00ed peptid zkouman\u00fd v laboratorn\u00edch modelech pro selektivn\u00ed po\u0161kozen\u00ed ur\u010dit\u00fdch n\u00e1dorov\u00fdch bun\u011bk.<\/p>\n<p><strong>\u2022&nbsp; HDM2 na bun\u011b\u010dn\u00e9 membr\u00e1n\u011b: <\/strong>Navrhovan\u00fd mechanismus souvis\u00ed s vazbou na HDM2, kter\u00fd se u n\u011bkter\u00fdch n\u00e1dorov\u00fdch bun\u011bk nach\u00e1z\u00ed i na vn\u011bj\u0161\u00edm povrchu membr\u00e1ny.<\/p>\n<p><strong>\u2022&nbsp; Tvorba membr\u00e1nov\u00fdch p\u00f3r\u016f: <\/strong>V bun\u011b\u010dn\u00fdch modelech se zkoum\u00e1 vytv\u00e1\u0159en\u00ed p\u00f3r\u016f v membr\u00e1n\u011b a n\u00e1sledn\u00e1 ztr\u00e1ta integrity n\u00e1dorov\u00e9 bu\u0148ky; klinick\u00e1 \u00fa\u010dinnost u lid\u00ed nebyla prok\u00e1z\u00e1na.<\/p>\n<h2>Dosavadn\u00ed zji\u0161t\u011bn\u00ed v\u00fdzkumu<\/h2>\n<p>Dosavadn\u00ed pr\u00e1ce u l\u00e1tky PNC-27 se v\u011bnuj\u00ed oblastem, mezi kter\u00e9 pat\u0159\u00ed n\u00e1dorov\u00e9 bu\u0148ky, HDM2 na membr\u00e1n\u011b, tvorba membr\u00e1nov\u00fdch p\u00f3r\u016f. V\u00fdsledky je t\u0159eba posuzovat podle \u00farovn\u011b d\u016fkaz\u016f: bun\u011b\u010dn\u00e9 a zv\u00ed\u0159ec\u00ed modely. Jedn\u00e1 se p\u0159ev\u00e1\u017en\u011b o bun\u011b\u010dn\u00fd a preklinick\u00fd v\u00fdzkum.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Produkt PNC-27 se dod\u00e1v\u00e1 jako 5 mg lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 sklen\u011bn\u00e9 vialce. Ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010den pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed.<\/p>\n","protected":false},"featured_media":550,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[19],"product_tag":[39,40,41],"class_list":["post-553","product","type-product","status-publish","has-post-thumbnail","product_cat-imunitne-zdravie","product_tag-lyophilised","product_tag-research-use-only","product_tag-third-party-tested","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.6 (Yoast SEO v25.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PNC-27 5 mg - VirexionLabs.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/virexionlabs.net\/cs\/produkt\/pnc-27-5mg\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PNC-27 5 mg\" \/>\n<meta property=\"og:description\" content=\"Produkt PNC-27 se dod\u00e1v\u00e1 jako 5 mg lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 sklen\u011bn\u00e9 vialce. 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