{"id":379,"date":"2026-10-27T12:15:14","date_gmt":"2026-10-27T12:15:14","guid":{"rendered":"https:\/\/virexionlabs.net\/product\/foxo4-dri-10mg\/"},"modified":"2026-10-27T12:15:14","modified_gmt":"2026-10-27T12:15:14","slug":"foxo4-dri-10mg","status":"publish","type":"product","link":"https:\/\/virexionlabs.net\/cs\/produkt\/foxo4-dri-10mg\/","title":{"rendered":"FOXO4-DRI 10 mg"},"content":{"rendered":"

FOXO4-DRI je experiment\u00e1ln\u00ed peptid navr\u017een\u00fd k naru\u0161en\u00ed interakce mezi FOXO4 a p53 v senescentn\u00edch bu\u0148k\u00e1ch. P\u0159edklinick\u00fd v\u00fdzkum zkoum\u00e1, zda t\u00edm lze selektivn\u011b podpo\u0159it apopt\u00f3zu ur\u010dit\u00fdch st\u00e1rnouc\u00edch bun\u011bk. Z\u00e1jem vznikl v oblasti senolytik a biologick\u00e9ho st\u00e1rnut\u00ed.<\/p>\n

Co je FOXO4-DRI?<\/h2>\n

FOXO4-DRI se \u0159ad\u00ed mezi l\u00e1tky typu \u201esyntetick\u00fd peptid nebo peptidov\u00fd analog\u201c a v odborn\u00e9m v\u00fdzkumu se hodnot\u00ed v souvislosti s oblastmi jako senescentn\u00ed bu\u0148ky, foxo4-p53 interakce, tk\u00e1\u0148ov\u00e9 st\u00e1rnut\u00ed, senolytick\u00fd v\u00fdzkum. Pozornost se v\u011bnuje jeho interakci s p\u0159\u00edslu\u0161n\u00fdmi receptory, enzymy nebo bun\u011b\u010dn\u00fdmi dr\u00e1hami a n\u00e1sledn\u00fdm zm\u011bn\u00e1m m\u011b\u0159iteln\u00fdch laboratorn\u00edch parametr\u016f.<\/p>\n

Mechanismus zkouman\u00e9ho p\u016fsoben\u00ed<\/h2>\n

FOXO4-DRI m\u00e1 naru\u0161it vazbu FOXO4 na p53. V senescentn\u00edch bu\u0148k\u00e1ch to m\u016f\u017ee p\u0159esunout p53 a podpo\u0159it apoptotick\u00fd program; tento mechanismus je preklinick\u00fd.<\/p>\n

Hlavn\u00ed oblasti v\u00fdzkumu<\/h2>\n

\u2022  Senescentn\u00ed bu\u0148ky: <\/strong>FOXO4-DRI byl navr\u017een pro v\u00fdzkum bun\u011bk, kter\u00e9 p\u0159estaly d\u011blit, ale z\u016fst\u00e1vaj\u00ed metabolicky aktivn\u00ed a mohou ovliv\u0148ovat okoln\u00ed tk\u00e1\u0148.<\/p>\n

\u2022  Interakce FOXO4\u2013p53: <\/strong>Peptid naru\u0161uje vazbu mezi FOXO4 a p53, kter\u00e1 v senescentn\u00edch bu\u0148k\u00e1ch pom\u00e1h\u00e1 udr\u017eovat p53 mimo mechanismy vedouc\u00ed k bun\u011b\u010dn\u00e9 smrti.<\/p>\n

\u2022  Senolytick\u00fd v\u00fdzkum: <\/strong>P\u0159edklinick\u00e9 pr\u00e1ce zkoumaj\u00ed selektivn\u00ed odstran\u011bn\u00ed \u010d\u00e1sti senescentn\u00edch bun\u011bk a n\u00e1sledn\u00e9 zm\u011bny funkce tk\u00e1n\u00ed.<\/p>\n

\u2022  Tk\u00e1\u0148ov\u00e9 st\u00e1rnut\u00ed: <\/strong>V\u00fdzkum hodnot\u00ed, zda sn\u00ed\u017een\u00ed z\u00e1t\u011b\u017ee senescentn\u00edmi bu\u0148kami ovliv\u0148uje v\u011bkov\u011b podm\u00edn\u011bn\u00e9 zm\u011bny org\u00e1n\u016f; klinick\u00e9 \u00fadaje u lid\u00ed zat\u00edm chyb\u00ed.<\/p>\n

Dosavadn\u00ed zji\u0161t\u011bn\u00ed v\u00fdzkumu<\/h2>\n

V\u00fdsledky je t\u0159eba posuzovat podle \u00farovn\u011b d\u016fkaz\u016f: bun\u011b\u010dn\u00e9 a zv\u00ed\u0159ec\u00ed. P\u0159edklinick\u00fd v\u00fdzkum zkoum\u00e1, zda t\u00edm lze selektivn\u011b podpo\u0159it apopt\u00f3zu ur\u010dit\u00fdch st\u00e1rnouc\u00edch bun\u011bk.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produkt FOXO4-DRI se dod\u00e1v\u00e1 jako 10 mg lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 sklen\u011bn\u00e9 vialce. Ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010den pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed.<\/p>\n","protected":false},"featured_media":376,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[20],"product_tag":[39,40,41],"class_list":["post-379","product","type-product","status-publish","has-post-thumbnail","product_cat-dlhovekost-a-anti-aging","product_tag-lyophilised","product_tag-research-use-only","product_tag-third-party-tested","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"\nFOXO4-DRI 10 mg - VirexionLabs.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/virexionlabs.net\/cs\/produkt\/foxo4-dri-10mg\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FOXO4-DRI 10 mg\" \/>\n<meta property=\"og:description\" content=\"Produkt FOXO4-DRI se dod\u00e1v\u00e1 jako 10 mg lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 sklen\u011bn\u00e9 vialce. 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